A new method to enhance drug delivery has been developed at UC Santa Barbara. The method utilizes a biological system of gaining access to cells.
One of the most difficult barriers to cross in drug delivery is the movement of the drug from the circulation into the tissue. This technique provides a ay of achieving this.
A nanoparticle can be attached to the N-terminus of a peptide, which posses a ‘motif’ that allows it to enter the cell. These motifs consist of amino acid sequences containing arginine and lysine, situated at the peptides C-terminus.
The team at UCSB have specifically targeted prostate cancer cells with this technique but reiterate that the technique can be applied to many different cell and tissue types.
This method of delivering the nanoparticles from the circulation into the tissue will increase the efficiency of drug delivery systems.
With another barrier crossed for successful nanoparticle drug delivery the day we may be able to implement these techniques will draw closer. This may prove to be a huge step towards having a fully functioning nanoparticle drug delivery system. – CT